Gabapentin Drug Interaction Alcohol (Ethyl): CNS Depressants may enhance the CNS depressant effect of Alcohol (Ethyl). Monitor therapy Alizapride: May enhance the CNS depressant effect of CNS Depressants. Monitor therapy Aluminum Hydroxide: May decrease the serum concentration of Gabapentin. Management: Administer gabapentin at least 2 hours after administration of antacids containing aluminum hydroxide or magnesium hydroxide. Consider… Continue reading Gabapentin Drug Interaction