Gabapentin Pharmacology

Gabapentin is structurally related to GABA. However, it does not bind to GABAA¬†or GABAB¬†receptors, and it does not appear to influence synthesis or uptake of GABA. High affinity gabapentin binding sites have been located throughout the brain; these sites correspond to the presence of voltage-gated calcium channels specifically possessing the alpha-2-delta-1 subunit. This channel appears… Continue reading Gabapentin Pharmacology